BIOQUANT

Genome Organization and Function in the Cell Nucleus

The activities associated with the genome center around the readout, processing, maintenance and transfer of the information encoded in the DNA sequence. In eukaryotes, the corresponding processes like gene expression and RNA processing, as well as DNA repair, replication, recombination and genome segregation take place in the environment of the nucleus. It provides a complex dynamic organization that serves to establish two apparently contradicting functions: On the one hand the genome has to be protected from uncontrolled modifications that would compromise its function, and it has to be reliably replicated and segregated during cell division and meiosis. On the other hand it has to be remarkably plastic to allow for a dynamic (re)organization so that the cell is able to adopt different functional states. To understand how this is accomplished, findings from research in genomics, chromatin, epigenetics and nuclear organization have to be integrated. This need is addressed in the book "Genome Organization and Function in the Cell Nucleus" by Karsten Rippe that was published in January 2012 by Wiley-VCH. It combines complementary and interconnected contributions from renowned experts in different fields of research into a novel approach to understand genome function. Take a look at the book in the Wiley Online Library or at Amazon.com or Amazon.de.

From the back cover: "By way of its clear and logical structure, as well as abundant high-resolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: replication, recombination, repair, and transcription. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come."

 

Rippe, K., ed. (2012). Genome organization and function in the cell nucleus, 594 pages, Wiley-VCH, Weinheim. ISBN: 3527326987

including three chapters with contributions from the editor:

Rippe, K. (2012). The folding of the nucleosome chain. In Genome organization and function in the cell nucleus, Rippe, K., ed., pp. 139-167, Wiley-VCH, Weinheim. Abstract | Reprint available on request

R20. Längst, G., Teif, V. B. & Rippe, K. (2012). Chromatin remodeling and nucleosome positioning. In Genome organization and function in the cell nucleus, Rippe, K., ed., pp. 111-138, Wiley-VCH, Weinheim. Abstract | Reprint available on request

R19. Strickfaden, H., Cremer, T. & Rippe, K. (2012). Higher order chromatin organization and dynamics. In Genome organization and function in the cell nucleus, Rippe, K., ed., pp. 417-447, Wiley-VCH, Weinheim. Abstract | Reprint available on request

Contact: E-Mail

to top of page