Stephan Tirier

Research Interest

Analysis of tumor cell heterogeneity in solid tumors and hematopoietic malignancies
Single cell (epi)genomics and its applications in translational/clinical research
Methods for spatially resolved analysis of gene expression
Single cell analysis at the interface between genomics and imaging

since 09/2018: Postdoc at the German Cancer Research center (Heidelberg, Germany) in the division of Chromatin Networks of Prof. Dr. Karsten Rippe
04/2015 - 08/2018: PhD student at the German Cancer Research center (Heidelberg, Germany) in the division of Theoretical Bioinformatics of Prof. Dr. Roland Eils in the intelligent imaging group of Dr. Christian Conrad
08/2012 - 12/2012: Erasmus internship in the laboratory of Prof. Dr. Birgitta Henriques-Normark and Prof. Dr. Staffan Normark (Microbial Pathogens); Karolinska Institute, Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden
10/2011 - 06/2014: University of Wuerzburg - Master program Biology (Major: Microbiology and Molecular Cell- and Developmental Biology; Thesis in the Young Investigator Group of Dr. Cynthia Sharma, Research Center for Infectious Diseases (ZINF) at the University of Wuerzburg, Germany
10/2008 - 07/2011: University of Wuerzburg - Bachelor program Biology (Major: Microbiology; Thesis in the Department of Microbiology of Prof. Dr. Thomas Rudel at the University of Wuerzburg, Germany

Tirier, S.M. ... Rippe, K., Raab, M.S. (2019) Dissecting Heterogeneity of Tumor Cells and Their Microenvironment in Refractory Multiple Myeloma. Blood, 134(Supplement_1), 571.
Tirier, S.M., ... Rippe, K., ...Conrad, C. (2019) Pheno-seq - linking visual features and gene expression in 3D cell culture systems. Scientific Reports, 9(1), 1-15.
Krieger, T. G.,Tirier, S.M., ... Conrad, C. (2019). Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics. BioRxiv, 630202.
Waschow, M., Wang, Q., Saary, P., Klein, C., Aschenbrenner, S., Jechow, K., Meier, L., Tirier, S.M. ..., Conrad, C. (2019). Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression. BioRxiv, 2019.12.15.876763.
Pernitzsch, S. R.,Tirier, S.M., Beier, D. & Sharma, C. M. A variable homopolymeric G-repeat defines small RNA-mediated posttranscriptional regulation of a chemotaxis receptor in Helicobacter pylori. Proc. Natl. Acad. Sci. 111, E501-E510 (2014).
Balaban, M., Baettig, P., Muschiol, S.,Tirier, S.M., Wartha, F., Normark, S., Henriques-Normark, B. Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation. Proc. Natl. Acad. Sci. 111, E758-E765 (2014).

Stephan Tirier

DKFZ & BioQuant Center

Division of Chromatin Networks

Im Neuenheimer Feld 267-BQ24

69120 Heidelberg

Germany

e-mail: s.tirier (at) dkfz.de