BIOQUANT > Research Groups > Genome Organisation & Function > People > Fabian Erdel

Fabian Erdel

Research Interests

Long-range gene regulation by enhancers and silencers
Biophysical properties of chromatin
Epigenetic memory

Publications

Erdel F, Rippe K. (2018).
Formation of chromatin subcompartments by phase separation.
Biophys J 114(10):2262-70.
Rademacher A, Erdel F, Trojanowski J, Schumacher S, Rippe K. (2017).
Real-time observation of light-controlled transcription in living cells.
J Cell Sci 130(24):4213-24.
Erdel F. (2017).
How communication between nucleosomes enables spreading and epigenetic memory of histone modifications.
Bioessays 39(12):1700053.
Hoffmeister H, Fuchs A, Erdel F, Pinz S, Gröbner-Ferreira R, Bruckmann A, Deutzmann R, Schwartz U, Maldonado R, Huber C, Dendorfer A, Rippe K, Längst G. (2017).
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
Nucleic Acids Res 45(18):10534-54.
Molitor J, Mallm JP, Rippe K, Erdel F. (2017).
Retrieving chromatin patterns from deep sequencing data using correlation functions.
Biophys J 112(3):473-490.
Erdel F, Kratz K, Willcox S, Griffith JD, Greene EC, de Lange T. (2017).
Telomere Recognition and Assembly Mechanism of Mammalian Shelterin.
Cell Rep 18(1):41-53.
Erdel F, Greene EC. (2016).
Generalized nucleation and looping model for epigenetic memory of histone modifications.
PNAS 113(29):E4180-9.
Erdel F, Baum M, Rippe K. (2015).
The viscoelastic properties of chromatin and the nucleoplasm revealed by scale-dependent protein mobility.
J Phys Condens Matter 27(6):064115.
Müller-Ott K, Erdel F, Matveeva A, Mallm JP, Rademacher A, Hahn M, Bauer C, Zhang Q, Kaltofen S, Schotta G, Höfer T, Rippe K. (2014).
Specificity, propagation, and memory of pericentric heterochromatin.
Mol Syst Biol 10(8):746.
Baum M, Erdel F, Wachsmuth M, Rippe K. (2014).
Retrieving the intracellular topology from multi-scale protein mobility mapping in living cells.
Nat Commun 5:4494.
Erdel F, Müller-Ott K, Rippe K. (2013).
Establishing epigenetic domains via chromatin-bound histone modifiers.
Ann NYAS 1305(1):29-43.
Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R. (2013).
SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling.
Mol Cell 51(4):454-68.
Teif VB, Erdel F, Beshnova DA, Vainshtein Y, Mallm JP, Rippe K. (2013).
Taking into account nucleosomes for predicting gene expression.
Methods 62(1):26-38.
Erdel F, Rippe K. (2012).
Quantifying transient binding of ISWI chromatin remodelers in living cells by pixel-wise photobleaching profile evolution analysis.
PNAS 109(47):E3221-30.
Erdel F, Rippe K. (2011).
Chromatin remodeling in mammalian cells by ISWI type complexes – where, when and why?
FEBS J. 278(19):3608-18.
Erdel F, Krug J, Längst G, Rippe K. (2011).
Targeting chromatin remodelers: signals and search mechanisms.
Biochim Biophys Acta 1809(9):497-508.
Erdel F, Rippe K. (2011).
Binding kinetics of human ISWI chromatin-remodelers to DNA repair sites elucidate their target location mechanism.
Nucleus 2(2):105-12.
Erdel F, Müller-Ott K, Baum M, Wachsmuth M, Rippe K. (2011).
Dissecting chromatin interactions in living cells from protein mobility maps.
Chromosome Res. 19(1):99-115.
Erdel F, Schubert T, Marth C, Längst G, Rippe K. (2010).
Human ISWI chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites.
PNAS 107(46):19873-8.
Müller KP, Erdel F, Caudron-Herger M, Marth C, Fodor BD, Richter M, Scaranaro M, Beaudouin J, Wachsmuth M, Rippe K. (2009).
Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy.
Biophys J. 97(11):2876-85.
Gunkel M, Erdel F, Rippe K, Lemmer P, Kaufmann R, Hörmann C, Amberger R, Cremer C. (2009).
Dual color localization microscopy of cellular nanostructures.
Biotechnol J. 4(6):927-38.
Heuvelman G, Erdel F, Wachsmuth M, Rippe K. (2009).
Analysis of protein mobilities and interactions in living cells by multifocal fluorescence fluctuation microscopy.
Eur Biophys J. 38(6):813-28.

Scientific Background

since 10/2016 Team leader in the Division Chromatin Networks at the DKFZ & BioQuant, Heidelberg
09/2014-09/2016 Postdoctoral fellow in the Greene Lab at Columbia University, New York, research topic: Single-molecule studies of chromatin proteins
12/2012-08/2014 Postdoctoral fellow in the Research Group Genome Organization & Function at the DKFZ & BioQuant, Heidelberg, research topic: Epigenetic chromatin patterns
10/2009-11/2012 PhD Thesis in Physics in the Research Group Genome Organization & Function, research topic: Fluorescence fluctuation microscopy-based readouts for chromatin remodeling activity
01/2008-02/2009 Diploma Thesis in Physics in the Research Group Genome Organization & Function, research topic: Dynamics of chromatin remodeling complexes
05-07/2007 BSc Thesis in Molecular & Cell Biology with the title Molecular Simulation of the Restriction Enzyme EcoRV in the group of J. C. Smith (Interdisciplinary Center for Scientific Computing, Heidelberg)

Awards

Long-Term Fellowship, EMBO, 2014
Nikon Young Scientist Award, German Society for Cell Biology, 2013
Annemarie Poustka Fellowship, German Cancer Research Center, 2009
Otto Haxel Award, Ruprecht Karl University of Heidelberg, Faculty of Physics, 2009