BIOQUANT > Research Groups > Genome Organization & Function > Teaching > Interactions of Proteins and Nucleic Acids I
Interactions of Proteins and Nucleic Acids - Biophysical Concepts and Theoretical Descriptions
Karsten Rippe, Thursday 14.15-15:45, Bioquant, INF 267, SR 041 (ground floor), Winter Term 2024/2025, lecture (2 hours per week) + written exercises (~1 hour per week), 4 Credit Points (ECTS)
Content
The lecture will covers various biophysical topics that are relevant for a quantitative description of interactions of proteins and nucleic acids. In includes a short introduction to proteins and nuclein acids and then covers the following aspects: Physicochemical interactions of biological macromolecules, hydrophobic interactions, solution thermodynamics, hydration, charges, polymer models helix-coil transitions, binding equilibria, binding kinetics, hydrodynamics, transport, diffusion and sedimentation.
Audience
Students of Biology/Physics/Chemistry
References
- K. E. van Holde, W. C. Johnson, & S. P. Ho, Principles of Physical Biochemistry 2nd edition, Prentice-Hall, 2005
- C. Cantor und P. Schimmel, Biophysical Chemistry, Vol I, II und III, Freeman Press, 1980
- P. Nelson, Biological Physics, Freeman, 2004.
- R. Philipps, J. Kondev, & J. Theriot, Physical Biology of the Cell, Garland Science, 2009
- R. Milo & R. Philipps, Cell Biology by the Numbers, 2015 http://book.bionumbers.org
Slides, references and additional information on the lectures (currently mostly from winter term 2020/2021)
Course materials Oct 2024 until Feb 2025
Problem sets
- Problem sets accompanying the lecture are handed out every two weeks (seven in total). Problem sets need to be returned within the deadline (usually 2 weeks) given on the problem set to Karsten.Rippe@bioquant.uni-heidelberg.de. Please include BPC2024 in the subject line. We will discuss the answers to the problem sets and any issues you encounter.
- The corrected problem sets will be returned together with the reference solution, which can be downloaded from the web page.
- Only the six highest-graded problem sets will be considered for your final grade, so you can still achieve 100% even if one problem set is missing. You must obtain at least 50% of the points to receive credit.
- You may work in groups to discuss the problem sets; however, each student must submit his/her answer separately.
- Here you can download the general information on the grading scheme.
Software Links
Contact: E-Mail
