Theses and patents
PhD Theses
24. Lukas Frank (2023). Perturbing and imaging nuclear compartments to reveal mechanisms of transcription regulation and telomere maintenance. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
23. Linda Schuster (2022). Dissecting heterogeneity, clonal evolution, and epigenetic changes in distinct and molecularly defined AML subsets by multi omics single-cell sequencing. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
22. Armin Hadzic (2022). Heterogeneity and multi-omics features of alternative lengthening of telomeres. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
21. Lara Klett (2021). Disease- and drug-induced chromatin state changes in blood cancers. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
20. Jorge Trojanowski (2021). Regulation of transcription by transcription factor residence time and multivalent interactions. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
19. Markus Muckenhuber (2020). Epigenetic signals that direct cell type specific interferon beta response in mouse cells. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
18. Alexandra Poos (2019). Mixed integer linear programming based approaches to study telomere maintenance mechanisms. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
17. Delia Maria Braun (2018). Inducing and suppressing the alternative lengthening of telomeres mechanism in cancer cells. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
16. Anne Rademacher (2017). Silencing and activating heterochromatin. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
15. Teresa Pankert (2016). A 3'-UTR sequence element modifies chromatin and regulates alternative splicing. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
14. Katharina Deeg (2015). Identifying drivers and suppressors of the alternative lengthening of telomeres pathway. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
13. Jana Molitor (2015). Chromatin remodeling during differentiation of embryonic stem cells. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
12. Jan-Philipp Mallm (2012). Identifying epigenetic signaling pathways in embryonic stem cells that are involved in the proliferation of cancer cells. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
11. Katharina Müller-Ott (2012.) Dissecting the epigentic network that defines pericentric heterochromatin in mouse fibroblasts. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
10. Fabian Erdel (2012). Tracing the Activity of ISWI Chromatin Remodelers in Living Cells with Fluorescence Fluctuation Microscopy based Approaches. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
09. Sarah Osterwald (2012). Dissecting the alternative lengthening of telomeres pathway in human cancer cells using a high-content confocal microscopy screening approach. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
08. Inn Chung (2011). Alternative Lengthening of Telomeres – associated promyelocytic leukemia nuclear bodies: structure, assembly and function. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
07. Ramona Ettig (2010). Nucleosome dynamics investigated by molecular dynamics and Monte-Carlo simulations. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
06. Gerrit Heuvelman (2008). Development and design of a spatially and temporally resolved fluorescence fluctuation microscope for the analysis of molecular mobilities and interactions. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
05. Thibaud Jegou (2007). Dynamics of telomeres in a telomerase negative human osteosarcoma cell line. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
04. Jacek Mazurkiewicz (2006). Mechanisms of chromatin assembly and remodeling. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
03. Felix Kepert (2005). Modulation of chromatin conformation by linker histone H1 and histone chaperone NAP1. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
02. Katalin Fejes Tóth (2004). From histones to chromosomes: in vivo and in vitro analysis of structural changes caused by linker histone H1, histone acetylation and histone chaperone NAP1. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
01. Sabine Vogel (2004). Mechanistic studies on transcription activation via DNA looping in a prokaryotic promoter-enhancer system. PhD Thesis, Ruprecht-Karls-Universität Heidelberg.
Master and Diploma Theses
18. Simon Steiger (2021). Computational workflows for the analysis of multiple myeloma derived single cell transcriptomic data. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
17. Isabelle Lander (2019). Site-specific recruitment of RNA to chromatin using engineered dCas9 complexes. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
16. Jana Tünnermann (2018). Heterochromatin protein 1α-driven phase separation. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
15. Lukas Frank (2017). Site-specific recruitment of RNA to chromatin using engineered dCas9 complexes. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
14. Andre Holzer (2017). Probing and Modulating Chromatin Accessibility to Investigate Enhancer-Promoter Wiring in Human Cells. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
13. Lisa Dressler (2017). Identifying gene expression targets of the deacetylase inhibitor panobinostat in multiple myeloma cell lines. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
12. Jorge Trojanowski (2016). Quantification and mechanistic modelling of light induced transcription to detect long lived promoter states. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
11. Sebastian Großmann (2015). Molecular targets of the histone deacetylase inhibitor panobinostat in chronic lymphocytic leukemia. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
10. Ronja Rappold (2015). Light-induced transcriptional activation. Bachelor Thesis, Ruprecht-Karls-Universität Heidelberg.
09. Jana Hechler (2014) Regulation of IFNβ-mediated JAK/STAT signaling by the chromatin environment . Master Thesis, Ruprecht-Karls-Universität Heidelberg
08. Carolin Böhm (2011). Expression, localization and functional analysis of the Snf2LΔNLS chromatin remodeler splice variant. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
07. Daniel Parisotto (2010). The role of HP1 and MMS21 in the alternative lengthening of telomeres. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
06. Michael Baum (2010). Implementation of new approaches for measuring protein dynamics by multifocal fluorescence laser microscopy. Diploma Thesis, Ruprecht-Karls-Universität Heidelberg.
05. Fabian Erdel (2009). Multi-scale fluorescence fluctuation microscopy: Dissecting diffusion, binding and directed motion of chromatin remodelers in living cells. Diploma Thesis, Ruprecht-Karls-Universität Heidelberg.
04. Katharina Müller (2008). Diffusion-interaction analysis of heterochromatin protein 1 in the nucleus by fluorescence fluctuation microscopy. Diploma Thesis, Ruprecht-Karls-Universität Heidelberg.
03. Sabine Kaltofen (2008). Heterochromatin Protein 1 - Struktur und Interaktionen mit Chromatin. Master Thesis, Ruprecht-Karls-Universität Heidelberg.
02. Evrim Ilden (2007). Monte Carlo simulations of chromatin fibers. Diploma Thesis, Ruprecht-Karls-Universität Heidelberg.
01. Felix Kepert (2006). Untersuchungen an Komplexen von H1 mit Mononukleosomen und freier DNA. Diploma Thesis, Ruprecht-Karls-Universität Heidelberg.
Patents
2. Wachsmuth, M., Rippe, K. & Heuvelman, G., published US patent application US 2006-0146325 A1 from January 4, 2006. “Setup for multifocal confocal microscopic determination of spatial distributions and for multifocal fluctuation analysis of fluorescent molecules and structures with spectrally variable detection”
1. Wachsmuth, M., Rippe, K. & Heuvelman, G., published German patent application DE 10 2005 000 915.8 from January 6, 2005. “Vorrichtung zur multifokalen konfokalen mikroskopischen Bestimmung der räumlichen Verteilung und zur multifokalen Fluktuationsanalyse von fluoreszenten Molekülen und Strukturen mit spektral flexibler Detektion”