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BIOQUANT > Research Groups > Genome Organisation & Function > People > Andre Holzer

Andre Holzer

Research Interest

The human genome undergoes a variety of (epi-)genetic alterations, potentially resulting in harmful diseases such as cancer. Remarkably many of these alterations reside in the non-coding portion of the genome where they are observed to modify enhancer regions. The latter belong to the class of cis-regulatory elements and are known to regulate gene expression via promoter interaction. However, mechanistic understanding of the enhancer-promoter interaction, also referred to as promoter-enhancer wiring is extremely limited.


We are particularly interested in investigating the complex interplay of epigenetic modifications, chromatin accessibility and promoter-enhancer wiring to understand in which way a distinct genetic alternation of an enhancer region influences gene regulation and potentially triggers disease development. In that manner, my research focuses on probing and modulating chromatin accessibility in human cells by combining modern single-cell sequencing with targeted epigenetic editing.


Scientific Background

Work experience

  • 2016:
    • since December: Master thesis, Genome Organization & Function Group
      DKFZ & BioQuant Center, Ruprecht-Karls University Heidelberg
    • Research intern, Optical Nanoscopy Group
      DKFZ & BioQuant Center, Ruprecht-Karls University Heidelberg
  • 2015:
    • Tutor, Physical Chemistry II
      IPMB, Ruprecht-Karls University Heidelberg
    • Reserach intern, Plant Metabolism Group
      Department of Plant Sciences, University of Cambridge
  • 2014:
    • Reserach intern, Plant Metabolism Group
      Department of Plant Sciences, University of Cambridge
    • Graduate research assistant, Theoretical and Computational Chemistry Group
      IWR, Ruprecht-Karls University Heidelberg
    • Reserach intern, Bacterial Signaling Network Group
      BioQuant/ZMBH, Ruprecht-Karls University Heidelberg
    • Research intern, Computational Oncology Group
      DKFZ, Ruprecht-Karls University Heidelberg
    • Graduate research assistant, Bacterial Signaling Network Group
      BioQuant/ZMBH, Ruprecht-Karls University Heidelberg
  • 2013:
    • Research intern, Bacterial Signaling Network Group
      BioQuant/ZMBH, Ruprecht-Karls University Heidelberg
    • Student assistant, Biocompatibility Laboratory
      Applications Engineering, Fresenius Medical Care St. Wendel
    • Research assistant, Theoretical and Computational Chemistry Group
      IWR, Ruprecht-Karls University Heidelberg

Education

  • since 2013: M.Sc. Molecular Biotechnology
    Ruprecht-Karls University Heidelberg
  • 2014 - 2015: Visiting student
    University of Cambridge, United Kingdom
  • 2010 - 2013: B.Sc. Molecular Biotechnology
    Ruprecht-Karls University Heidelberg
    Bachelor thesis: "FRET-biosensors for in vivo studies of PhrC signaling in Bacillus subtilis.", Bacterial Signaling Networks, ZMBH & BioQuant Center at Heidelberg University

Stipends

Publications

Helliwell K. E., Lawrence A. D., Holzer A., Kudahl U. J., Sasso S., Kräutler B., Scanlan D. J., Warren M. J. & Smith A. G. (2016) Cyanobacteria and Eukaryotic Algae Use Different Chemical Variants of Vitamin B12. Current Biology 26: 999-1008. doi: 10.1016/j.cub.2016.02.041

Wenzel J., Holzer A., Wormit M. & Dreuw A. (2015) Analysis and comparison of CVS-ADC approaches up to third order for the calcula on of core-excited states. The Journal of Chemical Physics 142: 214104. doi: 10.1063/1.4921841.

Contact

Andre Holzer

DKFZ & BioQuant Center

Research Group Genome Organization & Function

Im Neuenheimer Feld 267-BQ24

69120 Heidelberg

Germany


BioQuant room 623

Tel.: +49-6221-54-51374

Fax: +49 6221 54 51487


e-mail: andre.holzer (at) dkfz-heidelberg.de
e-mail: andre.holzer (at) bioquant.uni-heidelberg.de
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