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Portrait Lara Klett
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Lara Klett

Research Interest

At present, cancer therapy is changing fundamentally. As replacement for conventional therapy with cytotoxic agents, new individualized therapies are emerging treating patients with drugs specifically intervening molecular pathways with aberrant activity. Among those is a novel therapeutic approach for chronic lymphocytic leukemia (CLL) targeting aberrant B-cell receptor (BCR) signaling. As a deregulated chromatin landscape has been associated with the pathogenesis of CLL, I examine the impact of BCR signaling of malignant cells on the epigenetics landscape genome wide by measuring several chromatin features e.g. histone modifications and Tn5-transposase accessibility (ATAC-seq). In particular, I focus on the mapping of active enhancers to link them with the deregulated gene expression in CLL. In addition to the differences between patients and non-malignant controls as well as between patients, I am also interested in the genetic, epigenetic and transcriptomic intrapatient heterogeneity on the single cell level in response to treatment.

Scientific Background

  • since 07/2015: PhD student at the German Cancer Research Center in the research group “Chromatin networks” of Prof. Dr. Karsten Rippe
  • 04/2013 – 05/2013: Research intern in the “Systems Genetics and Precision Health” group of Prof. Dr. Lars Steinmetz at the European Molecular Biology Laboratory, Heidelberg
  • 11/2012 – 12/2012: Research intern in the “Modelling of Biological Processes” group of Prof. Dr. Ursula Kummer at the University of Heidelberg
  • 10/2011 – 6/2015: University of Heidelberg - Master program of Molecular Biosciences - Systems Biology (thesis in the “Systems Genetics and Precision Health” group of Prof. Dr. Lars Steinmetz at the European Molecular Biology Laboratory, Heidelberg)
  • 10/2008 – 07/2011: University of Heidelberg - Bachelor program of Molecular and Cellular Biology (thesis in the department of “Human Molecular Genetics” at the Institute of „Human Genetics“, Prof. Dr. Gudrun Rappold)

Stipends

  • PhD scholarship of the Helmholtz International Graduate School for Cancer Research, 2015

Publications

Contact

Lara Klett

DKFZ & BioQuant Center

Division of Chromatin Networks

Im Neuenheimer Feld 267-BQ24

69120 Heidelberg

Germany


BioQuant room 622a

Tel.: +49-6221-54-51373

Fax: +49 6221 54 51487


e-mail: l.klett(at)dkfz.de
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