Interactions of Proteins and Nucleic Acids - Biophysical Concepts and Theoretical Descriptions
Karsten Rippe, Tuesday 14.15-15:45, Bioquant, INF 267, SR 044 (ground floor), Winter Term 2014/2015, lecture (2 hours per week) + written exercises (~1 hour per week), 4 Credit Points (ECTS)
Content
The lecture will covers various biophysical topics that are relevant for a quantitative description of interactions of proteins and nucleic acids. In includes a short introduction to proteins and nuclein acids and then covers the following aspects: Physicochemical interactions of biological macromolecules, hydrophobic interactions, solution thermodynamics, hydration, charges, polymer models helix-coil transitions, binding equilibria, binding kinetics, hydrodynamics, transport, diffusion and sedimentation.
Audience
Students of Biology/Physics/Chemistry
References
- K. E. van Holde, W. C. Johnson, & S. P. Ho, Principles of Physical Biochemistry 2nd edition, Prentice-Hall, 2005
- C. Cantor und P. Schimmel, Biophysical Chemistry, Vol I, II und III, Freeman Press, 1980
- M. Daune, Molecular Biophysics, Oxford University Press, 1999
- P. Nelson, Biological Physics, Freeman, 2004.
Slides, references and additional information on the lectures (currently from winter term 2013/2014)
Course materials (Oct 14, 2014 until Feb 3, 2015)
Problem sets
To get a course certificate (= "Schein") 50% of the problems need to be solved. There will be about 10 problem sets total. For a graded certificate (= "benoteter Schein") grades will be given based on the total percentage of problems solved. One problem set can be selected for extra credit points, i. e. if one problem set is missing, it is still possible to get 100% total.
Software Links
