BIOQUANT

News

RNA glue for the protein assembly line

Oct 10/2015 - How RNA molecules regulate the structure of the nucleolus and drive protein production. more...

CSB2 Prize in Systems Biology awarded to Karsten Rippe

July 8/2015 - Karsten Rippe is laureate of the CSB2 Prize in Systems Biology 2015 (kindly sponsored by Merrimack Pharmaceuticals) more...

Alternative routes to immortality

June 12/2015 - Cancer cells make use of specific DNA repair enzymes to extend their telomeres to divide without limits. more...

Throwing a loop to silence gene expression

Sep 2/2014 - Cells attach epigenetic signals to their genome to select which part of their genetic information is used. In our recent study a comprehensive analysis was conducted to dissect the epigenetic network that silences pericentric heterochromatin (PCH) transcription in mouse fibroblasts. more...

The interior of a cell from a moving protein's point of view

Aug 4/2014 - Numerous obstacles posed by cellular subcompartments and structures constrain protein transport in the cell. We mapped the intracellular topology by tracing fluorescently labeled reporter proteins in living cells on multiple time and length scales. more...

Nucleosomes and DNA methylation – the ‘memory knots’ of the cell?

Aug 1/2014 - In a study headed by Vladimir Teif, we made progress to solve one of the many puzzles with respect to how epigenetic signals change the cell’s genome organization and expression program during development. more...

Michael Baum received his PhD degree

May 21/2014 - No PhD degree finishers in 2013 but here comes another one for 2014. Congratulations to Michael for his successful graduation.

Fabian Erdel receives the "Nikon Young Scientist Award" of the Deutsche Gesellschaft für Zellbiologie (DGZ)

March 22/2013 - Für seine Arbeiten zur Entwicklung und Anwendung einer neuen Messmethode in der Fluoreszenzmikroskopie, die Dr. Fabian Erdel im Rahmen seines Dissertationsvorhabens durchgeführt hat, wurde der Wissenschaftler mit dem "Nikon Young Scientist Award" der Deutschen Gesellschaft für Zellbiologie (DGZ) ausgezeichnet. Den mit 1.500 Euro dotierten Preis erhielt er am 22. März 2013 während einer gemeinsamen Tagung der DGZ und der Gesellschaft für Entwicklungsbiologie in Heidelberg. Dr. Erdel ist Mitglied der Arbeitsgruppe Genomorganisation und -funktion, die am BioQuant-Zentrum der Universität Heidelberg und dem Deutschen Krebsforschungszentrum angesiedelt ist. Die von ihm entwickelte Methode "Pixel-wise Photobleaching Profile Evolution Analysis" kann zur Mobilitätsmessung von Proteinen in lebenden Zellen eingesetzt werden.

Three PhD degrees in 4 weeks

November and Dezember 2012 - Fabian Erdel (Nov 15), Katharina Müller-Ott (Nov 21) and Jan Philipp Mallm (Dec 18) successfully passed the examination and received their PhD degrees. That yields an impressive rate of 0.75 PhDs per week for the Rippe lab. Looks though that we will not be able sustain this pace in the next year. more...

Need for speed – measuring genome interactions in living cells

November 2012 - A second is only a blink of an eye in our daily life. However, a lot is happening within one second to a protein in the nucleus of a living cell. We traced chromatin remodelers in living cells with ms time resolution to dissect their nucleosome interactions. more...

Nucleosome positioning during embryonic stem cell development

October 2012 - In our recent paper in Nature Structural & Molecular Biology, we identify features of nucleosome positioning at functional genomic elements during lineage commitment. The results reveal regulatory mechanisms of cell differentiation that involve nucleosome positioning. more...

Sarah Osterwald received her PhD degree

October 12/2012 - Sarah is first, the first PhD degree this year in the group.

The book has been published: Genome Organization and Function in the Cell Nucleus

January 2012 - It seemed to take forever but finally the book edited by Karsten has been published. It provides an integrated description of central genome associated processes in the nucleus that combines genomics, chromatin structure, epigenetics and nuclear architecture. more...

Telomeres, RNA and nucleosomes - five great papers from 2011

Fall 2011 - This fall we successfully finished studies on three important topics of our lab. The alternative telomere lengthening pathway, nuclear architecture by RNA and the regulation of DNA access for transcription factors by nucleosomes. more...

Chromatin remodeling in living cells

October 25/10 - How does a cell regulate the access to the information encoded in its DNA? We have conducted the first study of chromatin remodelers – the molecular machines that organize the genome and control the DNA accessibility – in living cells. more...

German version

PML nuclear bodies in 3D

February 4/10 - Promyelocytic leukemia nuclear bodies (PML-NBs) are functionally heterogeneous structures involved in diverse nuclear functions like tumor suppression, telomere elongation and apoptosis. more...

Otto-Haxel award for Fabian Erdel

June 26/09 - Fabian Erdel has received the Otto-Haxel award of the Physics and Astronomy faculty for his Diploma thesis. more...

Cellular networks Postdoc programm Nov

March 12/09 - The Cellular Networks Cluster of Excellence in Heidelberg offers several postdoc positions for projects in the participating research groups of the cluster including our group. more...

Gerrit Heuvelman received his PhD degree

July 17/08 - Gerrit's colleagues came up with an impressive multifunctional "Doktorhut" that really challenges those of the previous ones. more...

Cellular networks Postdoc program May 2008

April 12/08 - The Cellular Networks Cluster of Excellence in Heidelberg offers several postdoc positions for projects in the participating research groups of the cluster including our group. more...

Lab opening party of the 6th floor groups

December 7/07 - Our group and those of Thomas Höfer and Ute Krämer had a nice get-together and lab opening with colleagues, friends & family. more...

Croissants & Coffee Seminars

November 18/07 - The seminars take place every three or four weeks on Friday 10 am in the in the Bioquant, seminar room 042 on the
ground floor. They are intended to bring together people from the Bioquant and the Bioquant network that
share common research interests on the seminar's topic. more...

"Research Highlight" article in Nature Reviews Genetics

October 29/07 - In the current issue of Nature Reviews Genetics a "Research Highlight" article entitled "Chromatin: Remodellers are more than just muscles" discusses our recent work on chromatin remodelers. more..

Maïwen Caudron-Herger at the "For Women in Science" award ceremony

September 25/07 - The national award ceremony of the program "For Women in Science" took place in Bonn for the first time in Germany. more...

PNAS publishes paper on chromatin remodeling

September 24/07 - The collaborative work with Gernot Längst's group provides new insights into chromatin remodeling. more...

Maïwen Caudron-Herger receives award

August 13/07 - Maïwen has been selected by the Christiane Nüsslein-Volhard-Foundation and the L'Oréal-Unesco "For Women in Science" program. more...

Lab team beats group leader

August 7/07 -The lab team with Maïwen, Didi and Gerrit beats Karsten at the Heidelbergman triathlon. more...

Thibaud Jegou received his PhD degree

July 27/07 - Congratulations Thibaud! This was probably the first graduation of a member of the BIOUANT. more...

Moving into the BIOQUANT

July 12/07 - On July 3 we have moved into the new BIOQUANT-building. more...