BIOQUANT

Research

As an interdisciplinary group that integrates molecular/cell biology, physics and chemistry we deal with diverse methods and technologies to investigate the complex organizational and structural details of chromatin. The following list covers the main projects we are currently working on. For an overview of techniques that are used within the group within the research topics listed below, take a look at Methods.

Epigenetic Regulation

  • Mechanisms of chromatin regulation by RNA
  • Chromatin states and transcriptional dynamics
  • Cause and consequence of chromatin alterations on IFNβ-induced gene expression

Nuclear Organization

Chromatin in Leukemia

  • Chronic lymphocytic leukemia (CLL)
  • Acute myeloid leukemia (AML)
  • Multiple myeloma (MM)

Telomere maintenance

In vivo recruitment and high-throughput screening of protein factors involved in the Alternative Lengthening of Telomeres (ALT) pathway in telomerase-negative cancer cells. A comprehensive analysis of telomere maintenance mechanisms and telomeric chromatin networks in glioblastoma and protstate cancer is conducted within a BMBF consortium project. The project is coordinated by Karsten Rippe and is part of the e:Med Systems Medicine Program. For more information see www.CancerTelSys.org