Throwing a loop to silence gene expression
September 2, 2014 - Cells attach epigenetic signals to their genome to select which part of their genetic information is used. In our recent study a comprehensive analysis was conducted to dissect the epigenetic network that silences pericentric heterochromatin (PCH) transcription in mouse fibroblasts. more...

The interior of a cell from a moving protein's point of view
August 4, 2014 - Numerous obstacles posed by cellular subcompartments and structures constrain protein transport in the cell. We mapped the intracellular topology by tracing fluorescently labeled reporter proteins in living cells on multiple time and length scales. more...

Nucleosomes and DNA methylation – the 'memory knots' of the cell?
August 1, 2014 -In a study headed by Vladimir Teif, we made progress to solve one of the many puzzles with respect to how epigenetic signals change the cell's genome organization and expression program during development. more...

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Genome Organization & Function

Research focus

The Genome Organization & Function group at the BioQuant is an interdisciplinary research team from the German Cancer Research Center (DKFZ). We combine molecular/cell biology and physics to develop quantitative descriptions that relate the dynamic organization of the (epi)genome with gene expression programs and functional cell states.

RNA in Chromatin Structure Epigenetic Networks Alternative Lengthening of Telomeres Chromatin Remodelers Chromatin Fibers Fluorescence Imaging Modeling of DNA Accessibility Single Cell Manipulations Fluctuation Microscopy Deep Sequencing

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